Probing the Ionization State of the Universe at z>6

We present high signal-to-noise ratio Keck ESI spectra of the two quasars known to have Gunn-Peterson absorption troughs, SDSS J1030+0524 (z=6.28) and SDSS J1148+5251 (z=6.37). The Ly alpha and Ly beta troughs for SDSS J1030+0524 are very black and show no evidence for any emission over a redshift interval of ~0.2 starting at z=6. On the other hand, SDSS J1148+5251 shows a number of emission peaks in the Ly beta Gunn-Peterson trough along with a single weak peak in the Ly alpha trough. The Ly alpha emission has corresponding Ly beta emission, suggesting that it is indeed a region of lower optical depth in the intergalactic medium at z=6.08. The stronger Ly beta peaks in the spectrum of SDSS J1148+5251 could conceivably also be the result of "leaks" in the IGM, but we suggest that they are instead Ly alpha emission from an intervening galaxy at z=4.9. This hypothesis gains credence from a strong complex of C IV absorption at the same redshift and from the detection of continuum emission in the Ly alpha trough at the expected brightness. If this proposal is correct, the quasar light has probably been magnified through gravitational lensing by the intervening galaxy. The Stromgren sphere observed in the absorption spectrum of SDSS J1148+5251 is significantly smaller than expected based on its brightness, which is consistent with the hypothesis that the quasar is lensed. If our argument for lensing is correct, the optical depths derived from the troughs of SDSS J1148+5251 are only lower limits (albeit still quite strong, with tau(LyA)>16 inferred from the Ly beta trough.) The Ly beta absorption trough of SDSS J1030+0524 gives the single best measurement of the IGM transmission at z>6, with an inferred optical depth tau(LyA)>22.Comment: To appear in July 2003 AJ, 34 pages, 11 figures; minor changes/typos fixe

Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies

Irreversible electroporation (IRE) is a promising non-thermal treatment for inoperable tumors which uses short (50–100 μs) high voltage monopolar pulses to disrupt the membranes of cells within a well-defined volume. Challenges with IRE include complex treatment planning and the induction of intense muscle contractions. High frequency IRE (H-FIRE) uses bursts of ultrashort (0.25–5 μs) alternating polarity pulses to produce more predictable ablations and alleviate muscle contractions associated with IRE. However, H-FIRE generally ablates smaller volumes of tissue than IRE. This study shows that asymmetric H-FIRE waveforms can be used to create ablation volumes equivalent to standard IRE treatments. Lethal thresholds (LT) of 505 V/cm and 1316 V/cm were found for brain cancer cells when 100 μs IRE and 2 μs symmetric H-FIRE waveforms were used. In contrast, LT as low as 536 V/cm were found for 2 μs asymmetric H-FIRE waveforms. Reversible electroporation thresholds were 54% lower than LTs for symmetric waveforms and 33% lower for asymmetric waveforms indicating that waveform symmetry can be used to tune the relative sizes of reversible and irreversible ablation zones. Numerical simulations predicted that asymmetric H-FIRE waveforms are capable of producing ablation volumes which were 5.8–6.3x larger than symmetric H-FIRE waveforms indicating that in vivo investigation of asymmetric waveforms is warranted

Complex Power Distribution Network Investigation Using SPICE Based Extraction from First Principle Formulations

The modeling and the analysis of the power distribution networks (PDN) within multi-layer printed circuit board is crucial for the investigation of the performance of PCB systems. Carrying out such analyses in SPICE based tools has the advantage of being faster than the corresponding full-wave modeling and it allows obtaining both frequency and time domain results

The impact of computed high b-value images on the diagnostic accuracy of DWI for prostate cancer: A receiver operating characteristics analysis.

To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s/mm2), apparent diffusion coefficient (ADC) maps, and computed high b-value images (contrast equivalent to b = 2000 s/mm2) to compare their diagnostic accuracy. Receiver operating characteristic (ROC) analysis and McNemar's test were performed to assess the relative performance of computed high b value DWI, native high b-value DWI and ADC maps. No significant difference existed in the area under the curve (AUC) for ROCs comparing B1200 (b = 1200 s/mm2) to computed B2000 (c-B2000) in 5 readers. In 4 of 5 readers c-B2000 had significantly increased sensitivity and/or decreased specificity compared to B1200 (McNemar's p < 0.05), at selected thresholds of interpretation. ADC maps were less accurate than B1200 or c-B2000 for 2 of 5 readers (P < 0.05). This study detected no consistent improvement in overall diagnostic accuracy using c-B2000, compared with B1200 images. Readers detected more cancer with c-B2000 images (increased sensitivity) but also more false positive findings (decreased specificity)

The Phoenix Deep Survey: Extremely Red Galaxies and Cluster Candidates

We present the results of a study of a sample of 375 Extremely Red Galaxies (ERGs) in the Phoenix Deep Survey, 273 of which constitute a subsample which is 80% complete to K_s = 18.5 over an area of 1160 arcmin^2. The angular correlation function for ERGs is estimated, and the association of ERGs with faint radio sources explored. We find tentative evidence that ERGs and faint radio sources are associated at z > 0.5. A new overdensity-mapping algorithm has been used to characterize the ERG distribution, and identify a number of cluster candidates, including a likely cluster containing ERGs at 0.5 < z < 1. Our algorithm is also used in an attempt to probe the environments in which faint radio sources and ERGs are associated. We find limited evidence that the I - K_s > 4 criterion is more efficient than R - K_s > 5 at selecting dusty star-forming galaxies, rather than passively evolving ERGs.Comment: 14 emulateapj pages, 15 figures, 1 table, accepted for publication in Astronomical Journal. A version with full resolution figures is available at http://www.physics.usyd.edu.au/~asmith/research/ERGpaper.pd

DC Power-Bus Noise Isolation with Power-Plane Segmentation

Power-plane segmentation is often used for DC power-bus noise isolation in multilayer printed circuit board (PCB) designs. To achieve a desirable noise isolation, different power-plane segmentations can be used. A suitable modeling approach, as well as measurements, were employed in this work to study the noise isolation with several power-plane segmentation designs. The geometries studied include power islands, and totally segmented power planes. The effects of the power-bus noise isolation with different types of power island connections, locations of segmentation, and shapes were analyzed, and compared. The modeled and measured results show that suitable power-plane segmentation can result in significant power-bus noise isolation

Single-walled carbon nanotubes in superacid: X-ray and calorimetric evidence for partly ordered H\u3csub\u3e2\u3c/sub\u3eSO\u3csub\u3e4\u3c/sub\u3e

Liquid anhydrous sulfuric acid forms a partly ordered structure in the presence of single-walled carbon nanotubes (SWNTs). X-ray scattering from aligned fibers immersed in acid shows the formation of molecular shells wrapped around SWNTs. Differential scanning calorimetry of SWNT-acid suspensions exhibits concentration-dependent supercooling/melting behavior, confirming that the partly ordered molecules are a new phase. We propose that charge transfer between nanotube π electrons and highly oxidizing superacid is responsible for the unique partly ordered structure

Predictive Modeling of the Effects of Skew and Imbalance on Radiated EMI from Cables

This paper provides an approach for predicting the effects of skew and imbalance on radiated emission of cables inside a commercial 19-inch rack-based cabinet. Scattering parameters (S-parameters) for two sets of cable assembly are measured with a four-port vector network analyzer (VNA) and converted into mixed mode S-parameters. Time-domain input signals with different slew rates and different amount of skew are transferred into frequency-domain using fast Fourier transform (FFT). The spectra of radiation emission associated with different inputs are then estimated

Modeling Noise Coupling from Non-Parallel PCB Trace Routing

Coupling between PCB signal traces in proximity is of concern to PCB designers and EMC engineers. The behavior of noise coupling between non-parallel microstrip lines is studied in this paper by a full-wave numerical modeling method CEMPIE, designating a circuit extraction approach based on a mixed-potential integral equation formulation. Good agreement between the numerical results and measurements was obtained